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6. Returns - still worried that even after all of the above your Obesity wont be what you want? Check out the returns policy. There is so much competition now that someone, somewhere is bound to offer the terms that you are comfortable with.

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8. Security - check for the yellow padlock on the Obesity site before you buy, and the s after http:/ /i.e. https:// = a secure site

9. Contact - got a question about Obesity, or want to leave a comment then check out the sites contact page. Reputable companies have them and respond.

10. Payment - ready to pay for your Obesity, then use your credit card or PayPal! Be aware of companies that don't accept them, there may be genuine reasons but given the huge amount of choice you have when buying online there is no reason at all not to buy via credit card or PayPal.

{{DiseaseDisorder infobox | Name = Obesity | Image = Obesity-waist circumference.PNG | Caption = Silhouettes representing healthy, overweight, and obese. | DiseasesDB = 9099 | ICD10 = {{ICD10|E|66| |e|65--> | ICD9 = {{ICD9|278--> | MedlinePlus = 003101 | eMedicineSubj = med | eMedicineTopic =1653 | MeshName = Obesity | MeshNumber = C23.888.144.699.500 | -->

Obesity is a condition in which the natural energy reserve, stored in the adipose tissue of humans and other mammals, is increased to a point where it is associated with certain health conditions or increased death.

Although obesity is an individual clinical condition, it is increasingly viewed as a serious and growing public health problem: excessive body weight has been shown to predispose to various diseases, particularly cardiovascular diseases, diabetes mellitus type 2, sleep apnea and osteoarthritis.U.S. Dept. of Health and Human Services, National Institutes of Health. "Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report" (2000). NHLBI document 98-4083. PDF fulltext

Definition Obesity can be defined in absolute or relative terms. In practical settings, obesity is typically evaluated in absolute terms by measuring BMI (body mass index), but also in terms of its distribution through waist circumference or waist-hip circumference ratio measurements. In addition, the presence of obesity needs to be regarded in the context of other risk factors and morbidity (other medical conditions that could influence risk of complications).

BMI BMI, or body mass index, is a simple and widely used method for estimating body fat.Mei Z, Grummer-Strawn LM, Pietrobelli A, Goulding A, Goran MI, Dietz WH. Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents. Am J Clin Nutr 2002;75:978-85. PMID 12036802. In epidemiology BMI alone is used as an indicator of prevalence and incidence.

BMI was developed by the Belgium statistician and anthropometry Adolphe Quetelet.Quetelet LAJ (1871). Antropométrie ou Mesure des Différences Facultés de l'Homme. Brussels: Musquardt. It is calculated by dividing the subject's weight by the square of his/her height, typically expressed either in Metric system or US customary units units:

Metric: BMI = kg/m^2

Where kg is the subject's weight in kilograms and m is the subject's height in metres.

US/Customary: BMI=lb*703/in^2

Where lb is the subject's weight in pound (mass) and in is the subject's height in inches.

The current definitions commonly in use establish the following values, agreed in 1997 and published in 2000:World Health Organization. Technical report series 894: "Obesity: preventing and managing the global epidemic.". Geneva: World Health Organization, 2000. PDF. ISBN 92-4-120894-5.

In a clinical setting, physicians take into account race, ethnicity, lean mass (muscularity), age, sex, and other factors which can affect the interpretation of BMI. BMI overestimates body fat in persons who are very muscular, and it can underestimate body fat in persons who have lost body mass (e.g. many elderly). Mild obesity as defined by BMI alone is not a cardiac risk factor, and hence BMI cannot be used as a sole clinical and epidemiological predictor of cardiovascular health.Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, Mookadam F, Lopez-Jimenez F. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet 2006;368:666-78. PMID 16920472

Waist circumference BMI does not take into account differing ratios of adipose to lean tissue; nor does it distinguish between differing forms of adiposity, some of which may correlate more closely with cardiovascular risk. Increasing understanding of the biology of different forms of adipose tissue has shown that visceral fat or central obesity (male-type or apple-type obesity) has a much stronger correlation, particularly with cardiovascular disease, than the BMI alone.

The absolute waist circumference (>102 cm in men and >88 cm in women) or waist-hip ratio (>0.9 for men and >0.85 for women) are both used as measures of central obesity.

Body fat measurement An alternative way to determine obesity is to assess percent body fat. Doctors and scientists generally agree that men with more than 25% body fat and women with more than 30% body fat are obese. However, it is difficult to measure body fat precisely. The most accepted method has been to weigh a person underwater, but underwater weighing is a procedure limited to laboratories with special equipment. Two simpler methods for measuring body fat are the skinfold test, in which a pinch of skin is precisely measured to determine the thickness of the subcutaneous fat layer; or bioelectrical impedance analysis, usually only carried out at specialist clinics. Their routine use is discouraged.National Institute for Health and Clinical Excellence. Clinical guideline 43: Obesity: the prevention, identification, assessment and management of overweight and obesity in adults and children. London, 2006.

Other measurements of body fat include computed tomography (CT/CAT scan), magnetic resonance imaging (MRI/NMR), and dual energy X-ray absorptiometry (DXA).Vanhecke TE, Franklin BA, Lillystone MA, Sandberg KR, deJong AT, Krause KR, Chengelis DL, McCullough PA. Caloric expenditure in the morbidly obese using dual energy X-ray absorptiometry. J Clin Densitomet 2006;9:438-444. PMID 17097530.

Risk factors and comorbidities The presence of risk factors and diseases associated with obesity are also used to establish a clinical diagnosis. Coronary heart disease, Diabetes mellitus type 2, and sleep apnea are possible life-threatening risk factors that would indicate clinical treatment of obesity. Smoking, hypertension, age and family history are other risk factors that may indicate treatment.

Effects on health A large number of medical conditions have been associated with obesity. Health consequences are categorised as being the result of either increased fat mass (osteoarthritis, obstructive sleep apnea, social stigma) or increased number of fat cells (diabetes mellitus, cancer, cardiovascular disease, non-alcoholic fatty liver disease). Mortality is increased in obesity, with a BMI of over 32 being associated with a doubled risk of death. There are alterations in the body's response to insulin (insulin resistance), a inflammation and an increased tendency to thrombosis (prothrombotic state).

Disease associations may be dependent or independent of the distribution of adipose tissue. Central obesity (male-type or waist-predominant obesity, characterised by a high waist-hip ratio), is an important risk factor for the metabolic syndrome, the clustering of a number of diseases and risk factors that heavily predispose for cardiovascular disease. These are diabetes mellitus type 2, hypertension, hypercholesterolemia, and hypertriglyceridemia (combined hyperlipidemia).

Apart from the metabolic syndrome, obesity is also correlation with a variety of other complications. For some of these complaints, it has not been clearly established to what extent they are caused directly by obesity itself, or have some other cause (such as limited exercise) that causes obesity as well.

While being severely obese has many health ramifications, those who are somewhat overweight face little increased mortality or morbidity. Osteoporosis is known to occur less in slightly overweight people.

Causes and mechanisms Lifestyle Most researchers have concluded that the combination of an excessive nutrient intake and a sedentary lifestyle are the main cause for the rapid acceleration of obesity in Western society in the last quarter of the 20th century. Sara Bleich, David Cutler, Christopher Murray, Alyce Adams. Why is the Developed World Obese? National Bureau of Economic Research Working Paper No. 12954. Issued in March 2007.

Despite the widespread availability of nutritional information in schools, doctors' offices, on the internet and on groceries,Centers for Disease Control and Prevention. Nutrition For Everyone. National Control for Health Statistics. Accessed July 15, 2007. it is evident that overeating remains a substantial problem. For instance, reliance on food energy fast-food meals tripled between 1977 and 1995, and calorie intake quadrupled over the same period.Lin BH, Guthrie J and Frazao E (1999). "Nutrient contribution of food away from home". In: Frazao E (Ed). America's Eating Habits: Changes and Consequences. Agriculture Information Bulletin No. 750, US Department of Agriculture, Economic Research Service, Washington, DC, pp. 213–239. Fulltext index.

However, dietary intake in itself is insufficient to explain the phenomenal rise in levels of obesity in much of the industrialized world during recent years. An increasingly sedentary lifestyle also has a significant role to play. More and more research into child obesity, for example, links such things as school run, with the current high levels of this disease. http://politics.guardian.co.uk/publicservices/story/0,,2147839,00.html

Less well established life style issues which may influence obesity include a Stress (medicine) mentality and insufficient sleep.

Genetics As with many medical conditions, the calorific imbalance that results in obesity often develops from a combination of genetic and environmental factors. Polymorphism (biology)s in various genes controlling appetite, metabolism, and adipokine release predispose to obesity, but the condition requires availability of sufficient calories, and possibly other factors, to develop fully. Various genetic conditions that feature obesity have been identified (such as Prader-Willi syndrome, Bardet-Biedl syndrome, MOMO syndrome, leptin receptor mutations and melanocortin receptor mutations), but known single-locus mutations have been found in only about 5% of obese individuals. While it is thought that a large proportion of the causative genes are still to be identified, much obesity is likely the result of interactions between multiple genes, and non-genetic factors are likely also important.

A 2007 study identified fairly common mutations in the FTO gene; heterozygotes had a 30% increased risk of obesity, while homozygotes faced a 70% increased risk.

On a population level, the thrifty gene hypothesis postulates that certain ethnic groups may be more prone to obesity than others, and the ability to take advantage of rare periods of abundance and use such abundance by storing energy efficiently may have been an evolutionary advantage in times when food was scarce. Individuals with greater adipose reserves were more likely to survive famine. This tendency to store fat is likely maladaptive in a society with stable food supplies.

Medical illness Certain physical and mental illnesses and particular pharmaceutical substances may predispose to obesity. Apart from the fact that correcting these situations may improve the obesity, the presence of increased body weight may complicate the management of others.

Medical illnesses that increase obesity risk include several rare congenital syndromes (listed above), hypothyroidism, Cushing's syndrome, growth hormone deficiency. Smoking cessation is a known cause for moderate weight gain, as nicotine suppresses appetite. Certain medications (e.g. glucocorticoids, atypical antipsychotics, some fertility medication) may cause weight gain.

Mental illnesses may also increase obesity risk, specifically some eating disorders (bulimia nervosa and binge eating disorder).

Neurobiological mechanisms s such as mouse to conduct experiments.

Flier summarizes the many possible pathophysiology mechanisms involved in the development and maintenance of obesity. This field of research had been almost unapproached until leptin was discovered in 1994. Since this discovery, many other hormonal mechanisms have been elucidated that participate in the regulation of appetite and food intake, storage patterns of adipose tissue, and development of insulin resistance. Since leptin's discovery, ghrelin, orexin, PYY 3-36, cholecystokinin, adiponectin, and many other mediators have been studied. The adipokines are mediators produced by adipose tissue; their action is thought to modify many obesity-related diseases.

Leptin and ghrelin are considered to be complementary in their influence on appetite, with ghrelin produced by the stomach modulating short-term appetitive control (i.e. to eat when the stomach is empty and to stop when the stomach is stretched). Leptin is produced by adipose tissue to signal fat storage reserves in the body, and mediates long-term appetitive controls (i.e. to eat more when fat storages are low and less when fat storages are high). Although administration of leptin may be effective in a small subset of obese individuals who are leptin deficient, many more obese individuals are thought to be leptin resistant. This resistance is thought to explain in part why administration of leptin has not been shown to be effective in suppressing appetite in most obese subjects.

While leptin and ghrelin are produced peripherally, they control appetite through their actions on the central nervous system. In particular, they and other appetite-related hormones act on the hypothalamus, a region of the brain central to the regulation of food intake and energy expenditure. There are several circuits within the hypothalamus that contribute to its role in integrating appetite, the melanocortin pathway being the most well understood. The circuit begins with an area of the hypothalamus, the arcuate nucleus, that has outputs to the lateral hypothalamus (LH) and ventromedial hypothalamus (VMH), the brain's feeding and satiety centers, respectively.

The arcuate nucleus contains two distinct groups of neurons. The first group coexpresses neuropeptide Y (NPY) and agouti-related peptide (AgRP) and has stimulatory inputs to the LH and inhibitory inputs to the VMH. The second group coexpresses pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) and has stimulatory inputs to the VMH and inhibitory inputs to the LH. Consequently, NPY/AgRP neurons stimulate feeding and inhibit satiety, while POMC/CART neurons stimulate satiety and inhibit feeding. Both groups of arcuate nucleus neurons are regulated in part by leptin. Leptin inhibits the NPY/AgRP group while stimulating the POMC/CART group. Thus a deficiency in leptin signaling, either via leptin deficiency or leptin resistance, leads to overfeeding and may account for some genetic and acquired forms of obesity.

Microbiological aspects The role of bacteria colonizing the digestive tract in the development of obesity has recently become the subject of investigation. Bacteria participate in digestion (especially of fatty acids and polysaccharides), and alterations in the proportion of particular strains of bacteria may explain why certain people are more prone to weight gain than others. Human digestive tract are generally either members of the phyla of bacteroidetes or of firmicutes. In obese people, there is a relative abundance of firmicutes (which cause relatively high energy absorption), which is restored by weight loss. From these results it cannot yet be concluded whether this imbalance is the cause of obesity or an effect.

Social determinants Some obesity co-factors are resistant to the theory that the "epidemic" is a new phenomenon. In particular, a social class co-factor consistently appears across many studies. Comparing net worth with BMI scores, a 2004 studyZagorsky JL. Is Obesity as Dangerous to Your Wealth as to Your Health? Res Aging 2004;26:130-152. PDF fulltext.. found obese American subjects approximately half as wealthy as thin ones. When income differentials were factored out, the inequity persisted—thin subjects were inheriting more wealth than fat ones. A higher rate of a lower level of education and tendencies to rely on cheaper fast foods is seen as a reason why these results are so dissimilar. Another study finds women who married into higher status are predictably thinner than women who married into lower status.

A 2007 study of more than 32,500 people indicated that people risked being obese if their friends, siblings or spouse were. The cohort was followed for 32 years. Friends (especially same-sex peers and even those many miles away) were the most important factor; this would indicate that social factors are a major determinant of body mass - either through behavioral issues or acceptance of increased body mass.

Therapy The mainstay of treatment for obesity is an energy-limited dieting and increased Physical exercise. In studies, diet and exercise programs have consistently produced an average weight loss of approximately 8% of total body mass (excluding study drop-outs). While not all dieters will be satisfied with this outcome, studies have shown that a loss of as little as 5% of body mass can create large health benefits. A more intractable Sociotherapy problem appears to be weight loss maintenance. Of dieters who manage to lose 10% or more of their body mass in studies, 80-95% will regain that weight within two to five years, supporting the finding that the body has various mechanisms that maintain weight at a certain set point.

In a clinical practice guideline by the American College of Physicians, the following five recommendations are made: Fulltext.
  • People with a BMI of over 30 should be counseled on diet, exercise and other relevant behavioral interventions, and set a realistic goal for weight loss.
  • If these goals are not achieved, pharmacotherapy can be offered. The patient needs to be informed of the possibility of Adverse effect (medicine) and the unavailability of long-term safety and efficacy data.
  • Drug therapy may consist of sibutramine, orlistat, phentermine, diethylpropion, fluoxetine, and bupropion. For more severe cases of obesity, stronger drugs such as amphetamine and methamphetamine may be used on a selective basis. Evidence is not sufficient to recommend sertraline, topiramate, or zonisamide.
  • In patients with BMI > 40 who fail to achieve their weight loss goals (with or without medication) and who develop obesity-related complications, referral for bariatric surgery may be indicated. The patient needs to be aware of the potential complications.
  • Those requiring bariatric surgery should be referred to high-volume referral centers, as the evidence suggests that surgeons who frequently perform these procedures have fewer complications.


    • A clinical practice guideline by the US Preventive Services Task Force (USPSTF) concluded that the evidence is insufficient to recommend for or against routine behavioral counseling to promote a healthy diet in unselected patients in primary care settings, but that intensive behavioral dietary counseling is recommended in those with hyperlipidemia and other known risk factors for cardiovascular and diet-related chronic disease. Intensive counseling can be delivered by primary care clinicians or by referral to other specialists, such as nutritionists or dietitians.

    Counseling A meta-analysis of randomized controlled trials concluded that "compared with usual care, dietary counseling interventions produce modest weight losses that diminish over time."

    Diets Various dietary approaches have been proposed, some of which have been compared by randomized controlled trials: "all 4 diets resulted in modest statistically significant weight loss at 1 year, with no statistically significant differences between diets" "The higher discontinuation rates for the Atkins and Ornish diet groups suggest many individuals found these diets to be too extreme"

    Low carbohydrate versus low fat Many studies have focused on diets that reduce calories via a low-carbohydrate (Atkins diet, Zone diet) diet versus a low-fat diet (LEARN diet, Ornish diet). The Nurses' Health Study, an observational cohort study, found that low carbohydrate diets based on vegetable sources of fat and protein are associated with less coronary heart disease.

    A meta-analysis of randomized controlled trials by the international Cochrane Collaboration in 2002 concluded that fat-restricted diets are no better than calorie restricted diets in achieving long term weight loss in overweight or obese people.

    A more recent meta-analysis that included randomized controlled trials published after the Cochrane review found that "low-carbohydrate, non-energy-restricted diets appear to be at least as effective as low-fat, energy-restricted diets in inducing weight loss for up to 1 year. However, potential favorable changes in triglyceride and high-density lipoprotein cholesterol values should be weighed against potential unfavorable changes in low-density lipoprotein cholesterol values when low-carbohydrate diets to induce weight loss are considered."

    The Women's Health Initiative Randomized Controlled Dietary Modification Trial found that a diet of total fat to 20% of energy and increasing consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 servings daily:

    Additional recent randomized controlled trials have found that:

    In young adults "Reducing glycemic load may be especially important to achieve weight loss among individuals with high insulin secretion." This is consistent with prior studies of diabetic patients in which low carbohydrate diets were more beneficial.

    Low glycemic index "The glycaemic index factor is a ranking of foods based on their overall effect on blood sugar levels. Low glycaemic index foods, such as lentils, provide a slower more consistent source of glucose to the bloodstream, thereby stimulating less insulin release than high glycaemic index foods, such as white bread."

    The glycemic load is "the mathematical product of the glycemic index and the carbohydrate amount".

    In a randomized controlled trial that compared four diets that varied in carbohydrate amount and glycemic index found complicated results:

    Diets 2 and 3 lost the most weight and fat mass; however, low density lipoprotein fell in Diet 2 and rose in Diet 3. Thus the authors concluded that the high-carbohydrate, low-glycemic index diet was the most favorable.

    A meta-analysis by the Cochrane Collaboration concluded that low glycemic index or low glycemic load diets led to more weight loss and better lipid profiles. However, the Cochrane Collaboration grouped low glycemic index and low glycemic load diets together and did not try to separate the effects of the load versus the index.

    Exercise A meta-analysis of randomized controlled trials by the international Cochrane Collaboration found that "exercise combined with diet resulted in a greater weight reduction than diet alone".

    Drugs A meta-analysis of randomized controlled trials by the international Cochrane Collaboration concluded that in diabetic patients found: "Fluoxetine, orlistat, and sibutramine can achieve statistically significant weight loss over 12 to 57 weeks. The magnitude of weight loss is modest, however, and the long-term health benefits remain unclear. The safety of sibutramine is uncertain. There is a paucity of data on other drugs for weight loss or control in persons with type 2 diabetes."

    Medication most commonly prescribed for diet/exercise-resistant obesity is orlistat (Xenical, which reduces intestinal fat absorption by inhibiting pancreas lipase) and sibutramine (Reductil, Meridia, an anorectic). In the presence of diabetes mellitus, there is evidence that the anti-diabetic drug metformin (Glucophage) can assist in weight loss—rather than sulfonylurea derivatives and insulin, which often lead to further weight gain. The thiazolidinediones (rosiglitazone or pioglitazone) can cause slight weight gain, but decrease the "pathologic" form of abdominal fat, and are therefore often used in obese diabetes mellitus.

    Bariatric surgery Bariatric surgery (or "weight loss surgery") is the use of surgical interventions in the treatment of obesity. As every surgical intervention may lead to complications, it is regarded as a last resort when dietary modification and pharmacological treatment have proven to be unsuccesful. Weight loss surgery relies on various principles; the most common approaches are reducing the volume of the stomach, producing an earlier sense of satiation (e.g. by adjustable gastric banding and Vertical banded gastroplasty surgery) while others also reduce the length of bowel that food will be in contact with, directly reducing absorption (gastric bypass surgery). Band surgery is reversible, while bowel shortening operations are not. Some procedures can be performed laparoscopic surgery. Complications from weight loss surgery are frequent.

    Two large studies have demonstrated a mortality benefit from bariatric surgery. A marked decrease in the risk of diabetes mellitus, cardiovascular disease and cancer. Weight loss was most marked in the first few months after surgery, but the benefit was sustained in the longer term. In one study there was an unexplained increase in deaths from accidents and suicide that did not outweigh the benefit in terms of disease prevention. Gastric bypass surgery was about twice as effective as banding procedures.

    Cultural and social significance Etymology Obesity is the nominal form of obese which comes from the Latin obēsus, which means "stout, fat, or plump." Ēsus is the past participle of edere (to eat), with ob added to it. In Classical Latin, this verb is seen only in past participial form. Its first attested usage in English language was in 1651, in Noah Biggs's Matæotechnia Medicinæ Praxeos.The Oxford English Dictionary (website)

    History In several human cultures, obesity was associated with physical attractiveness, physical strength, and fertility. Some of the earliest known cultural artifact (archaeology)s, known as Venus figurines, are pocket-sized statuettes representing an obese female figure. Although their cultural significance is unrecorded, their widespread use throughout pre-historic Mediterranean and European cultures suggests a central role for the obese female form in magic and religion rituals, and suggests cultural approval of (and perhaps reverence for) this body form. This is most likely due to their ability to easily bear children and survive famine.

    Obesity was considered a symbol of wealth and social status in cultures prone to food shortages or famine. Well into the early modern period in European cultures, it often served this role. But as food security was realized, it came to serve more as a visible signifier of "lust for life", appetite, and immersion in the realm of the eroticism.

    This was especially the case in the visual arts, such as the paintings of Peter Paul Rubens (1577–1640), whose regular depiction of fat women gives us the description Rubenesque. Obesity can also be seen as a symbol within a system of prestige. "The kind of food, the quantity, and the manner in which it is served are among the important criteria of social class. In most tribal societies, even those with a highly stratified social system, everyone - royalty and the commoners - ate the same kind of food, and if there was famine everyone was hungry. With the ever increasing diversity of foods, food has become not only a matter of social status, but also a mark of one's personality and taste."Powdermaker H. "An anthropological approach to the problem of obesity." In: Food and Culture: A Reader. Ed. Carole Counihan and Penny van Esterik. New York: Routledge, 1997;206. ISBN 0-415-91710-7.

    Contemporary culture In modern Western culture, the obese body shape is widely regarded as unattractive and many negative stereotypes are commonly associated with obese people. Obese children, teenagers and adults can also face a heavy social stigma. Obese children are frequently the targets of bullies and are often shunned by their peers. Although obesity rates are rising amongst all social classes in the West, obesity is often seen as a sign of lower socio-economic status. Greg Critser, Fat Land. Houghton Mifflin, NY, 2003. ISBN 0-14101-540-3. Most obese people have experienced negative thoughts about their body image, and some take drastic steps to try to change their shape including dieting, the use of diet pills, and even bariatrics.Not all contemporary cultures disapprove of obesity. There are many cultures which are traditionally more approving (to varying degrees) of obesity, including some African, Arabic, Indian, and Pacific Island cultures. Especially in recent decades, obesity has come to be seen more as a medical condition in modern Western culture even being referred to as an epidemic.

    Recently emerging is a small but vocal fat acceptance movement that seeks to challenge weight-based discrimination. Obesity acceptance and advocacy groups have initiated litigation to defend the rights of obese people and to prevent their social exclusion.Some notable figures within this movement, such as Paul Campos, argue that the social stigma surrounding obesity is founded in cultural anxiety, and that public concern over health risks associated with obesity are inappropriately used as a rationalization for this stigma. Paul Campos, The Diet Myth. Gotham Books, NY, 2004. ISBN 1-59240-135-X.

    Government agencies and private medicine have warned Americans for years of the adverse health effects associated with overweight and obesity. Despite the warnings, the problem is getting worse. In 2004, the CDC reported that 66.3% of adults in the United States were overweight or obese. The cause in most cases is a sedentary lifestyle; approximately 40% of adults in the United States do not participate in any leisure-time physical activity and less than 1/3 of adults engage in the recommended amount of physical activity.Centers for Disease Control and Prevention, National Center for Health Statistics, Fast Facts A to Z. Available at: http://www.cdc.gov/nchs/fastats/overwt.htm . Accessed July 15, 2007 Overweight and obesity are easily determined by using Body Mass Index (BMI); this index uses your weight and height to determine body fat. An index A BMI range of 25 to 29.9 is considered overweight and anything over 30 obese. Individuals with a BMI over 30 increase the risk of several heath hazards.The Surgeon General's call to action to prevent and decrease overweight andobesity; U.S. Dept. of Health and Human Services, Public Health Service, Office ofThe Surgeon General; Washington, D.C. Available at: http://www.surgeongeneral.gov/topics/obesity/calltoaction/CalltoAction.pdf . Accessed July 12, 2007

    Popular culture Various stereotypes of obese people have found their way into expressions of popular culture. A common stereotype is the obese character who has a warm and dependable personality, but equally common is the obese vicious bullying (such as Dursley Family#Dudley Dursley from the Harry Potter book series, Eric Cartman from South Park, Nelson Muntz from The Simpsons). Gluttony and obesity are commonly depicted together in works of fiction. In cartoons, obesity is often used to comedic effect, with fat cartoon characters (such as Piggy (Merrie Melodies), Porky Pig, Disney's Adventures of the Gummi Bears#Main characters, and Rupert (TV series)#Voice actors and their characters ) having to squeeze through narrow spaces, frequently getting stuck or even exploding.

    A more unusual example of obesity-related humour is Bustopher Jones, from the T.S. Eliot poem Bustopher Jones: The Cat About Town featured in his book Old Possum's Book of Practical Cats, as well as the musical Cats (musical), whose claim to fame is that he is a regular visitor to many gentlemen's clubs including Drones, Blimp's and the Tomb. Due to his constant lunching at these clubs, he is remarkably fat, being described by others as "a twenty-five pounder... And he's putting on weight everyday." Another popular character, Garfield, a cartoon cat, is also obese for humor. When his owner, Jon, puts him on diets, rather than losing weight, Garfield slows down his weight gain.

    It can be argued that depiction in popular culture adds to and maintains commonly perceived stereotypes, in turn harming the self esteem of obese people. On the other hand, obesity is often associated with positive characteristics such as good humour (the stereotype of the jolly fat man like Santa Claus), and some people are more sexual attraction to obese people than to slender people (see chubby culture, fat admirer).

    Public health and policy member countries.

    Prevalence United Kingdom The Health Survey for England predicts that more than 12 million adults and 1 million children will be obese by 2010 if no action is taken.BBC England to have 13m obese by 2010 25 August 2006 Forecasting obesity to 2010 The prime minister has urged people to take more responsibility for their fitness and diet.Guardian

    United States The prevalence of overweight and obesity in the United States makes obesity a leading public health problem. The United States has the highest rates of obesity in the developed world. From 1980 to 2002, obesity has doubled in adults and overweight prevalence has tripled in children and adolescents. From 2003-2004, "children and adolescents aged 2 to 19 years, 17.1% were overweight...and 32.2% of adults aged 20 years or older were obese." The prevalence in the United States continues to rise. The rapid epidemic of obesity in individual U.S. states from 1985-2004 can be seen here.

    China Because of the booming economy increasing average incomes, the population of China has recently begun a more sedentary lifestyle and at the same time begun consuming more calorie-rich foods. From 1991 to 2004 the percentage of adults who are overweight or obese increased from 12.9% to 27.3%. |pages= 94 |publisher= Scientific American |accessdate= |date= September, 2007-->

    Obesity is a public health and policy problem because of its prevalence, costs and burdens.U.S. Dept. of Health and Human Services, Public Health Service, Office of Surgeon General, The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity 2001 (2001) The prevalence of obesity has been continually rising for two decades.Centers for Disease Control and Prevention, U.S. Obesity Trends 1984 - 2002 . This sudden rise in obesity prevalence is attributed to environmental and population factors rather than individual behavior and biology because of the rapid and continual rise in the number of overweight and obese individuals.Morrill A, Chinn C. The obesity epidemic in the United States. J Public Health Policy 2004;25:353-366. PMID 15683071. The current environment produces risk factors for decreased physical activity and for increased calorie consumption. These environmental factors operate on the population to decrease physical activity and increase calorie consumption.

    Environmental factors While it may often appear obvious why a certain individual gets fat, it is far more difficult to understand why the average weight of certain societies have recently been growing. While genetic causes are central to understanding obesity, they cannot fully explain why one culture grows fatter than another.

    This is most notable in the United States. In the years from just after the Second World War until 1960 the average person's weight increased, but few were obese. In the two and a half decades since 1980 the growth in the rate of obesity has accelerated markedly and is increasingly becoming a public health concern.

    There are a number of theories as to the cause of this change since 1980. Most believe it is a combination of various factors.















    Public health and policy responses Kaiser Permanente facilities now provide oversized chairs such as this one at Richmond Medical Center, for obese patients.

    Public health and policy responses to obesity seek to understand and correct the environmental factors responsible for shifts in the prevalence of overweight and obesity in a population. Obesity and overweight are, currently, primarily policy problems in the United States. Policy and public health solutions look to change the environmental factors that promote calorie dense, low nutrient food consumption and that inhibit physical activity.

    In the United States, policy has focused primarily on controlling childhood obesity which has the most serious long-term public health implication. Efforts have been underway to target schools. There are efforts underway to reform federally-reimbursed meal programs, limit food marketing to children, and ban or limit access to sugar sweetened beverages. In Europe, policy has focused on limiting marketing to children. There has been international focus on sugar policy and the role of agriculture policy in producing food environments that produce overweight and obesity in a population. To confront physical activity, efforts have examined zoning and access parks and safe routes in cities.

    Non-medical consequences Besides increases in disease and mortality there are other implications of the present world trend in obesity. Among these are:

    See also

    References

    External links

    {{DiseaseDisorder infobox | Name = Obesity | Image = Obesity-waist circumference.PNG | Caption = Silhouettes representing healthy, overweight, and obese. | DiseasesDB = 9099 | ICD10 = {{ICD10|E|66| |e|65--> | ICD9 = {{ICD9|278--> | MedlinePlus = 003101 | eMedicineSubj = med | eMedicineTopic =1653 | MeshName = Obesity | MeshNumber = C23.888.144.699.500 | -->

    Obesity is a condition in which the natural energy reserve, stored in the adipose tissue of humans and other mammals, is increased to a point where it is associated with certain health conditions or increased death.

    Although obesity is an individual clinical condition, it is increasingly viewed as a serious and growing public health problem: excessive body weight has been shown to predispose to various diseases, particularly cardiovascular diseases, diabetes mellitus type 2, sleep apnea and osteoarthritis.U.S. Dept. of Health and Human Services, National Institutes of Health. "Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report" (2000). NHLBI document 98-4083. PDF fulltext

    Definition Obesity can be defined in absolute or relative terms. In practical settings, obesity is typically evaluated in absolute terms by measuring BMI (body mass index), but also in terms of its distribution through waist circumference or waist-hip circumference ratio measurements. In addition, the presence of obesity needs to be regarded in the context of other risk factors and morbidity (other medical conditions that could influence risk of complications).

    BMI BMI, or body mass index, is a simple and widely used method for estimating body fat.Mei Z, Grummer-Strawn LM, Pietrobelli A, Goulding A, Goran MI, Dietz WH. Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents. Am J Clin Nutr 2002;75:978-85. PMID 12036802. In epidemiology BMI alone is used as an indicator of prevalence and incidence.

    BMI was developed by the Belgium statistician and anthropometry Adolphe Quetelet.Quetelet LAJ (1871). Antropométrie ou Mesure des Différences Facultés de l'Homme. Brussels: Musquardt. It is calculated by dividing the subject's weight by the square of his/her height, typically expressed either in Metric system or US customary units units:

    Metric: BMI = kg/m^2

    Where kg is the subject's weight in kilograms and m is the subject's height in metres.

    US/Customary: BMI=lb*703/in^2

    Where lb is the subject's weight in pound (mass) and in is the subject's height in inches.

    The current definitions commonly in use establish the following values, agreed in 1997 and published in 2000:World Health Organization. Technical report series 894: "Obesity: preventing and managing the global epidemic.". Geneva: World Health Organization, 2000. PDF. ISBN 92-4-120894-5.

    In a clinical setting, physicians take into account race, ethnicity, lean mass (muscularity), age, sex, and other factors which can affect the interpretation of BMI. BMI overestimates body fat in persons who are very muscular, and it can underestimate body fat in persons who have lost body mass (e.g. many elderly). Mild obesity as defined by BMI alone is not a cardiac risk factor, and hence BMI cannot be used as a sole clinical and epidemiological predictor of cardiovascular health.Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, Mookadam F, Lopez-Jimenez F. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet 2006;368:666-78. PMID 16920472

    Waist circumference BMI does not take into account differing ratios of adipose to lean tissue; nor does it distinguish between differing forms of adiposity, some of which may correlate more closely with cardiovascular risk. Increasing understanding of the biology of different forms of adipose tissue has shown that visceral fat or central obesity (male-type or apple-type obesity) has a much stronger correlation, particularly with cardiovascular disease, than the BMI alone.

    The absolute waist circumference (>102 cm in men and >88 cm in women) or waist-hip ratio (>0.9 for men and >0.85 for women) are both used as measures of central obesity.

    Body fat measurement An alternative way to determine obesity is to assess percent body fat. Doctors and scientists generally agree that men with more than 25% body fat and women with more than 30% body fat are obese. However, it is difficult to measure body fat precisely. The most accepted method has been to weigh a person underwater, but underwater weighing is a procedure limited to laboratories with special equipment. Two simpler methods for measuring body fat are the skinfold test, in which a pinch of skin is precisely measured to determine the thickness of the subcutaneous fat layer; or bioelectrical impedance analysis, usually only carried out at specialist clinics. Their routine use is discouraged.National Institute for Health and Clinical Excellence. Clinical guideline 43: Obesity: the prevention, identification, assessment and management of overweight and obesity in adults and children. London, 2006.

    Other measurements of body fat include computed tomography (CT/CAT scan), magnetic resonance imaging (MRI/NMR), and dual energy X-ray absorptiometry (DXA).Vanhecke TE, Franklin BA, Lillystone MA, Sandberg KR, deJong AT, Krause KR, Chengelis DL, McCullough PA. Caloric expenditure in the morbidly obese using dual energy X-ray absorptiometry. J Clin Densitomet 2006;9:438-444. PMID 17097530.

    Risk factors and comorbidities The presence of risk factors and diseases associated with obesity are also used to establish a clinical diagnosis. Coronary heart disease, Diabetes mellitus type 2, and sleep apnea are possible life-threatening risk factors that would indicate clinical treatment of obesity. Smoking, hypertension, age and family history are other risk factors that may indicate treatment.

    Effects on health A large number of medical conditions have been associated with obesity. Health consequences are categorised as being the result of either increased fat mass (osteoarthritis, obstructive sleep apnea, social stigma) or increased number of fat cells (diabetes mellitus, cancer, cardiovascular disease, non-alcoholic fatty liver disease). Mortality is increased in obesity, with a BMI of over 32 being associated with a doubled risk of death. There are alterations in the body's response to insulin (insulin resistance), a inflammation and an increased tendency to thrombosis (prothrombotic state).

    Disease associations may be dependent or independent of the distribution of adipose tissue. Central obesity (male-type or waist-predominant obesity, characterised by a high waist-hip ratio), is an important risk factor for the metabolic syndrome, the clustering of a number of diseases and risk factors that heavily predispose for cardiovascular disease. These are diabetes mellitus type 2, hypertension, hypercholesterolemia, and hypertriglyceridemia (combined hyperlipidemia).

    Apart from the metabolic syndrome, obesity is also correlation with a variety of other complications. For some of these complaints, it has not been clearly established to what extent they are caused directly by obesity itself, or have some other cause (such as limited exercise) that causes obesity as well.

    While being severely obese has many health ramifications, those who are somewhat overweight face little increased mortality or morbidity. Osteoporosis is known to occur less in slightly overweight people.

    Causes and mechanisms Lifestyle Most researchers have concluded that the combination of an excessive nutrient intake and a sedentary lifestyle are the main cause for the rapid acceleration of obesity in Western society in the last quarter of the 20th century. Sara Bleich, David Cutler, Christopher Murray, Alyce Adams. Why is the Developed World Obese? National Bureau of Economic Research Working Paper No. 12954. Issued in March 2007.

    Despite the widespread availability of nutritional information in schools, doctors' offices, on the internet and on groceries,Centers for Disease Control and Prevention. Nutrition For Everyone. National Control for Health Statistics. Accessed July 15, 2007. it is evident that overeating remains a substantial problem. For instance, reliance on food energy fast-food meals tripled between 1977 and 1995, and calorie intake quadrupled over the same period.Lin BH, Guthrie J and Frazao E (1999). "Nutrient contribution of food away from home". In: Frazao E (Ed). America's Eating Habits: Changes and Consequences. Agriculture Information Bulletin No. 750, US Department of Agriculture, Economic Research Service, Washington, DC, pp. 213–239. Fulltext index.

    However, dietary intake in itself is insufficient to explain the phenomenal rise in levels of obesity in much of the industrialized world during recent years. An increasingly sedentary lifestyle also has a significant role to play. More and more research into child obesity, for example, links such things as school run, with the current high levels of this disease. http://politics.guardian.co.uk/publicservices/story/0,,2147839,00.html

    Less well established life style issues which may influence obesity include a Stress (medicine) mentality and insufficient sleep.

    Genetics As with many medical conditions, the calorific imbalance that results in obesity often develops from a combination of genetic and environmental factors. Polymorphism (biology)s in various genes controlling appetite, metabolism, and adipokine release predispose to obesity, but the condition requires availability of sufficient calories, and possibly other factors, to develop fully. Various genetic conditions that feature obesity have been identified (such as Prader-Willi syndrome, Bardet-Biedl syndrome, MOMO syndrome, leptin receptor mutations and melanocortin receptor mutations), but known single-locus mutations have been found in only about 5% of obese individuals. While it is thought that a large proportion of the causative genes are still to be identified, much obesity is likely the result of interactions between multiple genes, and non-genetic factors are likely also important.

    A 2007 study identified fairly common mutations in the FTO gene; heterozygotes had a 30% increased risk of obesity, while homozygotes faced a 70% increased risk.

    On a population level, the thrifty gene hypothesis postulates that certain ethnic groups may be more prone to obesity than others, and the ability to take advantage of rare periods of abundance and use such abundance by storing energy efficiently may have been an evolutionary advantage in times when food was scarce. Individuals with greater adipose reserves were more likely to survive famine. This tendency to store fat is likely maladaptive in a society with stable food supplies.

    Medical illness Certain physical and mental illnesses and particular pharmaceutical substances may predispose to obesity. Apart from the fact that correcting these situations may improve the obesity, the presence of increased body weight may complicate the management of others.

    Medical illnesses that increase obesity risk include several rare congenital syndromes (listed above), hypothyroidism, Cushing's syndrome, growth hormone deficiency. Smoking cessation is a known cause for moderate weight gain, as nicotine suppresses appetite. Certain medications (e.g. glucocorticoids, atypical antipsychotics, some fertility medication) may cause weight gain.

    Mental illnesses may also increase obesity risk, specifically some eating disorders (bulimia nervosa and binge eating disorder).

    Neurobiological mechanisms s such as mouse to conduct experiments.

    Flier summarizes the many possible pathophysiology mechanisms involved in the development and maintenance of obesity. This field of research had been almost unapproached until leptin was discovered in 1994. Since this discovery, many other hormonal mechanisms have been elucidated that participate in the regulation of appetite and food intake, storage patterns of adipose tissue, and development of insulin resistance. Since leptin's discovery, ghrelin, orexin, PYY 3-36, cholecystokinin, adiponectin, and many other mediators have been studied. The adipokines are mediators produced by adipose tissue; their action is thought to modify many obesity-related diseases.

    Leptin and ghrelin are considered to be complementary in their influence on appetite, with ghrelin produced by the stomach modulating short-term appetitive control (i.e. to eat when the stomach is empty and to stop when the stomach is stretched). Leptin is produced by adipose tissue to signal fat storage reserves in the body, and mediates long-term appetitive controls (i.e. to eat more when fat storages are low and less when fat storages are high). Although administration of leptin may be effective in a small subset of obese individuals who are leptin deficient, many more obese individuals are thought to be leptin resistant. This resistance is thought to explain in part why administration of leptin has not been shown to be effective in suppressing appetite in most obese subjects.

    While leptin and ghrelin are produced peripherally, they control appetite through their actions on the central nervous system. In particular, they and other appetite-related hormones act on the hypothalamus, a region of the brain central to the regulation of food intake and energy expenditure. There are several circuits within the hypothalamus that contribute to its role in integrating appetite, the melanocortin pathway being the most well understood. The circuit begins with an area of the hypothalamus, the arcuate nucleus, that has outputs to the lateral hypothalamus (LH) and ventromedial hypothalamus (VMH), the brain's feeding and satiety centers, respectively.

    The arcuate nucleus contains two distinct groups of neurons. The first group coexpresses neuropeptide Y (NPY) and agouti-related peptide (AgRP) and has stimulatory inputs to the LH and inhibitory inputs to the VMH. The second group coexpresses pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) and has stimulatory inputs to the VMH and inhibitory inputs to the LH. Consequently, NPY/AgRP neurons stimulate feeding and inhibit satiety, while POMC/CART neurons stimulate satiety and inhibit feeding. Both groups of arcuate nucleus neurons are regulated in part by leptin. Leptin inhibits the NPY/AgRP group while stimulating the POMC/CART group. Thus a deficiency in leptin signaling, either via leptin deficiency or leptin resistance, leads to overfeeding and may account for some genetic and acquired forms of obesity.

    Microbiological aspects The role of bacteria colonizing the digestive tract in the development of obesity has recently become the subject of investigation. Bacteria participate in digestion (especially of fatty acids and polysaccharides), and alterations in the proportion of particular strains of bacteria may explain why certain people are more prone to weight gain than others. Human digestive tract are generally either members of the phyla of bacteroidetes or of firmicutes. In obese people, there is a relative abundance of firmicutes (which cause relatively high energy absorption), which is restored by weight loss. From these results it cannot yet be concluded whether this imbalance is the cause of obesity or an effect.

    Social determinants Some obesity co-factors are resistant to the theory that the "epidemic" is a new phenomenon. In particular, a social class co-factor consistently appears across many studies. Comparing net worth with BMI scores, a 2004 studyZagorsky JL. Is Obesity as Dangerous to Your Wealth as to Your Health? Res Aging 2004;26:130-152. PDF fulltext.. found obese American subjects approximately half as wealthy as thin ones. When income differentials were factored out, the inequity persisted—thin subjects were inheriting more wealth than fat ones. A higher rate of a lower level of education and tendencies to rely on cheaper fast foods is seen as a reason why these results are so dissimilar. Another study finds women who married into higher status are predictably thinner than women who married into lower status.

    A 2007 study of more than 32,500 people indicated that people risked being obese if their friends, siblings or spouse were. The cohort was followed for 32 years. Friends (especially same-sex peers and even those many miles away) were the most important factor; this would indicate that social factors are a major determinant of body mass - either through behavioral issues or acceptance of increased body mass.

    Therapy The mainstay of treatment for obesity is an energy-limited dieting and increased Physical exercise. In studies, diet and exercise programs have consistently produced an average weight loss of approximately 8% of total body mass (excluding study drop-outs). While not all dieters will be satisfied with this outcome, studies have shown that a loss of as little as 5% of body mass can create large health benefits. A more intractable Sociotherapy problem appears to be weight loss maintenance. Of dieters who manage to lose 10% or more of their body mass in studies, 80-95% will regain that weight within two to five years, supporting the finding that the body has various mechanisms that maintain weight at a certain set point.

    In a clinical practice guideline by the American College of Physicians, the following five recommendations are made: Fulltext.
  • People with a BMI of over 30 should be counseled on diet, exercise and other relevant behavioral interventions, and set a realistic goal for weight loss.
  • If these goals are not achieved, pharmacotherapy can be offered. The patient needs to be informed of the possibility of Adverse effect (medicine) and the unavailability of long-term safety and efficacy data.
  • Drug therapy may consist of sibutramine, orlistat, phentermine, diethylpropion, fluoxetine, and bupropion. For more severe cases of obesity, stronger drugs such as amphetamine and methamphetamine may be used on a selective basis. Evidence is not sufficient to recommend sertraline, topiramate, or zonisamide.
  • In patients with BMI > 40 who fail to achieve their weight loss goals (with or without medication) and who develop obesity-related complications, referral for bariatric surgery may be indicated. The patient needs to be aware of the potential complications.
  • Those requiring bariatric surgery should be referred to high-volume referral centers, as the evidence suggests that surgeons who frequently perform these procedures have fewer complications.


    • A clinical practice guideline by the US Preventive Services Task Force (USPSTF) concluded that the evidence is insufficient to recommend for or against routine behavioral counseling to promote a healthy diet in unselected patients in primary care settings, but that intensive behavioral dietary counseling is recommended in those with hyperlipidemia and other known risk factors for cardiovascular and diet-related chronic disease. Intensive counseling can be delivered by primary care clinicians or by referral to other specialists, such as nutritionists or dietitians.

    Counseling A meta-analysis of randomized controlled trials concluded that "compared with usual care, dietary counseling interventions produce modest weight losses that diminish over time."

    Diets Various dietary approaches have been proposed, some of which have been compared by randomized controlled trials: "all 4 diets resulted in modest statistically significant weight loss at 1 year, with no statistically significant differences between diets" "The higher discontinuation rates for the Atkins and Ornish diet groups suggest many individuals found these diets to be too extreme"

    Low carbohydrate versus low fat Many studies have focused on diets that reduce calories via a low-carbohydrate (Atkins diet, Zone diet) diet versus a low-fat diet (LEARN diet, Ornish diet). The Nurses' Health Study, an observational cohort study, found that low carbohydrate diets based on vegetable sources of fat and protein are associated with less coronary heart disease.

    A meta-analysis of randomized controlled trials by the international Cochrane Collaboration in 2002 concluded that fat-restricted diets are no better than calorie restricted diets in achieving long term weight loss in overweight or obese people.

    A more recent meta-analysis that included randomized controlled trials published after the Cochrane review found that "low-carbohydrate, non-energy-restricted diets appear to be at least as effective as low-fat, energy-restricted diets in inducing weight loss for up to 1 year. However, potential favorable changes in triglyceride and high-density lipoprotein cholesterol values should be weighed against potential unfavorable changes in low-density lipoprotein cholesterol values when low-carbohydrate diets to induce weight loss are considered."

    The Women's Health Initiative Randomized Controlled Dietary Modification Trial found that a diet of total fat to 20% of energy and increasing consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 servings daily:

    Additional recent randomized controlled trials have found that:

    In young adults "Reducing glycemic load may be especially important to achieve weight loss among individuals with high insulin secretion." This is consistent with prior studies of diabetic patients in which low carbohydrate diets were more beneficial.

    Low glycemic index "The glycaemic index factor is a ranking of foods based on their overall effect on blood sugar levels. Low glycaemic index foods, such as lentils, provide a slower more consistent source of glucose to the bloodstream, thereby stimulating less insulin release than high glycaemic index foods, such as white bread."

    The glycemic load is "the mathematical product of the glycemic index and the carbohydrate amount".

    In a randomized controlled trial that compared four diets that varied in carbohydrate amount and glycemic index found complicated results:

    Diets 2 and 3 lost the most weight and fat mass; however, low density lipoprotein fell in Diet 2 and rose in Diet 3. Thus the authors concluded that the high-carbohydrate, low-glycemic index diet was the most favorable.

    A meta-analysis by the Cochrane Collaboration concluded that low glycemic index or low glycemic load diets led to more weight loss and better lipid profiles. However, the Cochrane Collaboration grouped low glycemic index and low glycemic load diets together and did not try to separate the effects of the load versus the index.

    Exercise A meta-analysis of randomized controlled trials by the international Cochrane Collaboration found that "exercise combined with diet resulted in a greater weight reduction than diet alone".

    Drugs A meta-analysis of randomized controlled trials by the international Cochrane Collaboration concluded that in diabetic patients found: "Fluoxetine, orlistat, and sibutramine can achieve statistically significant weight loss over 12 to 57 weeks. The magnitude of weight loss is modest, however, and the long-term health benefits remain unclear. The safety of sibutramine is uncertain. There is a paucity of data on other drugs for weight loss or control in persons with type 2 diabetes."

    Medication most commonly prescribed for diet/exercise-resistant obesity is orlistat (Xenical, which reduces intestinal fat absorption by inhibiting pancreas lipase) and sibutramine (Reductil, Meridia, an anorectic). In the presence of diabetes mellitus, there is evidence that the anti-diabetic drug metformin (Glucophage) can assist in weight loss—rather than sulfonylurea derivatives and insulin, which often lead to further weight gain. The thiazolidinediones (rosiglitazone or pioglitazone) can cause slight weight gain, but decrease the "pathologic" form of abdominal fat, and are therefore often used in obese diabetes mellitus.

    Bariatric surgery Bariatric surgery (or "weight loss surgery") is the use of surgical interventions in the treatment of obesity. As every surgical intervention may lead to complications, it is regarded as a last resort when dietary modification and pharmacological treatment have proven to be unsuccesful. Weight loss surgery relies on various principles; the most common approaches are reducing the volume of the stomach, producing an earlier sense of satiation (e.g. by adjustable gastric banding and Vertical banded gastroplasty surgery) while others also reduce the length of bowel that food will be in contact with, directly reducing absorption (gastric bypass surgery). Band surgery is reversible, while bowel shortening operations are not. Some procedures can be performed laparoscopic surgery. Complications from weight loss surgery are frequent.

    Two large studies have demonstrated a mortality benefit from bariatric surgery. A marked decrease in the risk of diabetes mellitus, cardiovascular disease and cancer. Weight loss was most marked in the first few months after surgery, but the benefit was sustained in the longer term. In one study there was an unexplained increase in deaths from accidents and suicide that did not outweigh the benefit in terms of disease prevention. Gastric bypass surgery was about twice as effective as banding procedures.

    Cultural and social significance Etymology Obesity is the nominal form of obese which comes from the Latin obēsus, which means "stout, fat, or plump." Ēsus is the past participle of edere (to eat), with ob added to it. In Classical Latin, this verb is seen only in past participial form. Its first attested usage in English language was in 1651, in Noah Biggs's Matæotechnia Medicinæ Praxeos.The Oxford English Dictionary (website)

    History In several human cultures, obesity was associated with physical attractiveness, physical strength, and fertility. Some of the earliest known cultural artifact (archaeology)s, known as Venus figurines, are pocket-sized statuettes representing an obese female figure. Although their cultural significance is unrecorded, their widespread use throughout pre-historic Mediterranean and European cultures suggests a central role for the obese female form in magic and religion rituals, and suggests cultural approval of (and perhaps reverence for) this body form. This is most likely due to their ability to easily bear children and survive famine.

    Obesity was considered a symbol of wealth and social status in cultures prone to food shortages or famine. Well into the early modern period in European cultures, it often served this role. But as food security was realized, it came to serve more as a visible signifier of "lust for life", appetite, and immersion in the realm of the eroticism.

    This was especially the case in the visual arts, such as the paintings of Peter Paul Rubens (1577–1640), whose regular depiction of fat women gives us the description Rubenesque. Obesity can also be seen as a symbol within a system of prestige. "The kind of food, the quantity, and the manner in which it is served are among the important criteria of social class. In most tribal societies, even those with a highly stratified social system, everyone - royalty and the commoners - ate the same kind of food, and if there was famine everyone was hungry. With the ever increasing diversity of foods, food has become not only a matter of social status, but also a mark of one's personality and taste."Powdermaker H. "An anthropological approach to the problem of obesity." In: Food and Culture: A Reader. Ed. Carole Counihan and Penny van Esterik. New York: Routledge, 1997;206. ISBN 0-415-91710-7.

    Contemporary culture In modern Western culture, the obese body shape is widely regarded as unattractive and many negative stereotypes are commonly associated with obese people. Obese children, teenagers and adults can also face a heavy social stigma. Obese children are frequently the targets of bullies and are often shunned by their peers. Although obesity rates are rising amongst all social classes in the West, obesity is often seen as a sign of lower socio-economic status. Greg Critser, Fat Land. Houghton Mifflin, NY, 2003. ISBN 0-14101-540-3. Most obese people have experienced negative thoughts about their body image, and some take drastic steps to try to change their shape including dieting, the use of diet pills, and even bariatrics.Not all contemporary cultures disapprove of obesity. There are many cultures which are traditionally more approving (to varying degrees) of obesity, including some African, Arabic, Indian, and Pacific Island cultures. Especially in recent decades, obesity has come to be seen more as a medical condition in modern Western culture even being referred to as an epidemic.

    Recently emerging is a small but vocal fat acceptance movement that seeks to challenge weight-based discrimination. Obesity acceptance and advocacy groups have initiated litigation to defend the rights of obese people and to prevent their social exclusion.Some notable figures within this movement, such as Paul Campos, argue that the social stigma surrounding obesity is founded in cultural anxiety, and that public concern over health risks associated with obesity are inappropriately used as a rationalization for this stigma. Paul Campos, The Diet Myth. Gotham Books, NY, 2004. ISBN 1-59240-135-X.

    Government agencies and private medicine have warned Americans for years of the adverse health effects associated with overweight and obesity. Despite the warnings, the problem is getting worse. In 2004, the CDC reported that 66.3% of adults in the United States were overweight or obese. The cause in most cases is a sedentary lifestyle; approximately 40% of adults in the United States do not participate in any leisure-time physical activity and less than 1/3 of adults engage in the recommended amount of physical activity.Centers for Disease Control and Prevention, National Center for Health Statistics, Fast Facts A to Z. Available at: http://www.cdc.gov/nchs/fastats/overwt.htm . Accessed July 15, 2007 Overweight and obesity are easily determined by using Body Mass Index (BMI); this index uses your weight and height to determine body fat. An index A BMI range of 25 to 29.9 is considered overweight and anything over 30 obese. Individuals with a BMI over 30 increase the risk of several heath hazards.The Surgeon General's call to action to prevent and decrease overweight andobesity; U.S. Dept. of Health and Human Services, Public Health Service, Office ofThe Surgeon General; Washington, D.C. Available at: http://www.surgeongeneral.gov/topics/obesity/calltoaction/CalltoAction.pdf . Accessed July 12, 2007

    Popular culture Various stereotypes of obese people have found their way into expressions of popular culture. A common stereotype is the obese character who has a warm and dependable personality, but equally common is the obese vicious bullying (such as Dursley Family#Dudley Dursley from the Harry Potter book series, Eric Cartman from South Park, Nelson Muntz from The Simpsons). Gluttony and obesity are commonly depicted together in works of fiction. In cartoons, obesity is often used to comedic effect, with fat cartoon characters (such as Piggy (Merrie Melodies), Porky Pig, Disney's Adventures of the Gummi Bears#Main characters, and Rupert (TV series)#Voice actors and their characters ) having to squeeze through narrow spaces, frequently getting stuck or even exploding.

    A more unusual example of obesity-related humour is Bustopher Jones, from the T.S. Eliot poem Bustopher Jones: The Cat About Town featured in his book Old Possum's Book of Practical Cats, as well as the musical Cats (musical), whose claim to fame is that he is a regular visitor to many gentlemen's clubs including Drones, Blimp's and the Tomb. Due to his constant lunching at these clubs, he is remarkably fat, being described by others as "a twenty-five pounder... And he's putting on weight everyday." Another popular character, Garfield, a cartoon cat, is also obese for humor. When his owner, Jon, puts him on diets, rather than losing weight, Garfield slows down his weight gain.

    It can be argued that depiction in popular culture adds to and maintains commonly perceived stereotypes, in turn harming the self esteem of obese people. On the other hand, obesity is often associated with positive characteristics such as good humour (the stereotype of the jolly fat man like Santa Claus), and some people are more sexual attraction to obese people than to slender people (see chubby culture, fat admirer).

    Public health and policy member countries.

    Prevalence United Kingdom The Health Survey for England predicts that more than 12 million adults and 1 million children will be obese by 2010 if no action is taken.BBC England to have 13m obese by 2010 25 August 2006 Forecasting obesity to 2010 The prime minister has urged people to take more responsibility for their fitness and diet.Guardian

    United States The prevalence of overweight and obesity in the United States makes obesity a leading public health problem. The United States has the highest rates of obesity in the developed world. From 1980 to 2002, obesity has doubled in adults and overweight prevalence has tripled in children and adolescents. From 2003-2004, "children and adolescents aged 2 to 19 years, 17.1% were overweight...and 32.2% of adults aged 20 years or older were obese." The prevalence in the United States continues to rise. The rapid epidemic of obesity in individual U.S. states from 1985-2004 can be seen here.

    China Because of the booming economy increasing average incomes, the population of China has recently begun a more sedentary lifestyle and at the same time begun consuming more calorie-rich foods. From 1991 to 2004 the percentage of adults who are overweight or obese increased from 12.9% to 27.3%. |pages= 94 |publisher= Scientific American |accessdate= |date= September, 2007-->

    Obesity is a public health and policy problem because of its prevalence, costs and burdens.U.S. Dept. of Health and Human Services, Public Health Service, Office of Surgeon General, The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity 2001 (2001) The prevalence of obesity has been continually rising for two decades.Centers for Disease Control and Prevention, U.S. Obesity Trends 1984 - 2002 . This sudden rise in obesity prevalence is attributed to environmental and population factors rather than individual behavior and biology because of the rapid and continual rise in the number of overweight and obese individuals.Morrill A, Chinn C. The obesity epidemic in the United States. J Public Health Policy 2004;25:353-366. PMID 15683071. The current environment produces risk factors for decreased physical activity and for increased calorie consumption. These environmental factors operate on the population to decrease physical activity and increase calorie consumption.

    Environmental factors While it may often appear obvious why a certain individual gets fat, it is far more difficult to understand why the average weight of certain societies have recently been growing. While genetic causes are central to understanding obesity, they cannot fully explain why one culture grows fatter than another.

    This is most notable in the United States. In the years from just after the Second World War until 1960 the average person's weight increased, but few were obese. In the two and a half decades since 1980 the growth in the rate of obesity has accelerated markedly and is increasingly becoming a public health concern.

    There are a number of theories as to the cause of this change since 1980. Most believe it is a combination of various factors.















    Public health and policy responses Kaiser Permanente facilities now provide oversized chairs such as this one at Richmond Medical Center, for obese patients.

    Public health and policy responses to obesity seek to understand and correct the environmental factors responsible for shifts in the prevalence of overweight and obesity in a population. Obesity and overweight are, currently, primarily policy problems in the United States. Policy and public health solutions look to change the environmental factors that promote calorie dense, low nutrient food consumption and that inhibit physical activity.

    In the United States, policy has focused primarily on controlling childhood obesity which has the most serious long-term public health implication. Efforts have been underway to target schools. There are efforts underway to reform federally-reimbursed meal programs, limit food marketing to children, and ban or limit access to sugar sweetened beverages. In Europe, policy has focused on limiting marketing to children. There has been international focus on sugar policy and the role of agriculture policy in producing food environments that produce overweight and obesity in a population. To confront physical activity, efforts have examined zoning and access parks and safe routes in cities.

    Non-medical consequences Besides increases in disease and mortality there are other implications of the present world trend in obesity. Among these are:

    See also

    References

    External links



    Obesity Introduction - Health encyclopaedia - NHS Direct
    Excess body fat ... Obesity is when a person is carrying too much body fat for their height and sex.

    Obesity
    The summary of the published clinical guideline on Obesity. It links to the published guidance and key documents.

    Obesity : Department of Health - Public health
    Obesity is associated with many illnesses and is directly related to increased mortality and lower life expectancy. Tackling obesity is a government wide priority. Obesity is ...

    Obesity Information @ HealthExpress.co.uk
    Obesity information for acomplia, reductil & xenical. Get obesity information and consultant from GMC certified doctors at free cost.

    Obesity
    Obesity is more than just a few extra pounds. Obesity is the heavy accumulation of fat in your body to such a degree that it rapidly increases your risk of diseases that can damage ...

    BBC NEWS | Politics | Johnson urges obesity 'movement'
    Alan Johnson calls for a "national movement" to tackle obesity and warns against "vilifying the extremely fat".

    BBC NEWS | Science/Nature
    Visit BBC News for up-to-the-minute news, breaking news, video, audio and feature stories. BBC News provides trusted World and UK news as well as local and regional perspectives.

    Clinical topic - Obesity - Clinical Knowledge Summaries
    Scenario: Obesity - assessment/referral: covers the assessment of, and when to refer, someone who is overweight or obese. Scenario: BMI 25-29.9 (overweight): covers the management ...

    Food Standards Agency - Eat well, be well - Obesity
    When someone is obese, it means they have put on weight to the point that it could seriously endanger their health.

    MedlinePlus: Obesity
    Obesity ... Obesity means having too much body fat. It is different from being overweight, which means weighing too much.

     

    Obesity



     
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